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- W2369965902 abstract "Objective To elucidate whether the antigen-processing gene(LMP2/LMP7) haplotypes were associated with the intestinal Mycobacterium tuberculosis(M.tuberculosis) infection in the Han nationality of China.Methods The association was analyzed in a hospital-based case control study of 189 intestinal M.tuberculosis cases and 221 cancer-free controls.DNA was obtained from blood samples and the LMP2-60/LMP7-145 was genotyped by the method of PCR-RFLP.The software PHASE1.0 was performed to construct the haplotype of every individual.The correlation was exhibited by the OR values(odds ratio) and their 95%CI(confidence intervals).After adjusting the confounding factors,unconditional logistic regression was used to analyze the statistical association of the two groups by using the SPSS11.5 software.Results The two polymorphisms in LMP2/LMP7 gene codon region were existence in our study population.In the two groups,both of the two loci genotype distributions were in Hardy-Weinberg equilibrium.Statistical analysis revealed that the allele frequency of the two polymorphisms did not display significant difference between the two groups(P0.05).Logistic regression analysis adjusted by confounding factors exhibited that the LMP2(Cys)-LMP7(Lys) haplotype possessed statistically difference(P=0.001,OR=4.02,95%CI: 2.48-9.62).Conclusion The haplotype constructed by the two polymorphisms of LMP2-60/LMP7-145 would increase the risk of intestinal M.tuberculosis infection in the Han nationality of China." @default.
- W2369965902 created "2016-06-24" @default.
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- W2369965902 date "2012-01-01" @default.
- W2369965902 modified "2023-09-27" @default.
- W2369965902 title "Susceptibility research of the haplotype from LMP2/LMP7 gene and intestinal mycobacterium tuberculosis infection" @default.
- W2369965902 hasPublicationYear "2012" @default.
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