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- W2369966725 abstract "Objective:To research the curative effect of letrozole in treatment of endometrial carcinoma by observing the changes of growth size of transplantable tumor,the changes of PTEN and Ki67 after establishing rat models of transplantable tumor by planting human endometrial carcinoma cell strain RL-952(positive estrogen receptor and progestogen receptor) into BALB/c female nude rats.Methods:Human endometrial carcinoma RL-952 cells at logarithmic growth phase were planted into nude rats to establish rat models of transplantable tumor,the rates were treated with letrozole,megestrol,letrozole combined with megestrol and normal saline,respectively;the effects of different drugs on the growth of transplantable tumor were compared.Results:The decrease extent of size of transplantable tumor in letrozole group after treatment was significantly lower than those in megestrol group and blank control group,but there was no significant difference in decrease extent of size of transplantable tumor between letrozole group and letrozole combined with megestrol group.The expression rates of PTEN in letrozole group,megestrol group and letrozole combined with megestrol group were significantly higher than that in blank control group,but there was no significant difference in expression rate of Ki-67 among the four groups.Conclusion:Letrozole inhibits transplantable tumor of endometrial carcinoma obviously,and its curative effect is superior to that of megestrol." @default.
- W2369966725 created "2016-06-24" @default.
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- W2369966725 date "2011-01-01" @default.
- W2369966725 modified "2023-09-25" @default.
- W2369966725 title "Experimental study on endometrial carcinoma treated by letrozole" @default.
- W2369966725 hasPublicationYear "2011" @default.
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