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- W2369968332 abstract "To establish a method for the determination of propofol in Beagel plasma by HPLC and study the protein binding rate of propofol microemulsion injection in plasma of Beagel by using plasma balance dialysis.Agilent C18(250 mm × 4.6 mm,5 μm) column was an analytical column and 0.01 mol/L ammonium acetate(pH 7.0)-acetonitrile(20:80,V/V) was mobile phase.The detection wavelength was 215 nm.Propofol had good linear relationship in the range of 5~600 ng/mL.The protein binding rates were(96.97±0.52)%,(97.73±0.76)%,(97.74±0.58)% when the concentrations of plasma propofol were 50,400 and 1000 ng/mL,respectively.The HPLC method used to determine propofol is accurate,sensitive and precise and with good specificity.Propofol microemulsion injection has high capacity in binding to plasma protein." @default.
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- W2369968332 date "2013-01-01" @default.
- W2369968332 modified "2023-09-23" @default.
- W2369968332 title "Determination of the plasma protein binding rate of propofol microemulsion injection in plasma of beagel" @default.
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