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- W2369968700 abstract "Objective:To investigate the value of the middle cerebral artery peak systolic velocity(MCA-PSV) by color Doppler ultrasonography in predicting fetal α-thalassemia.Methods:129 pregnancies at risk due to fetal α-thalassemia and 44 pregnancies of the normal control were performed with two-dimensional ultrasound and Doppler imaging.The MCA-PSV was measured.All fetuses of with risk of α-thalassemia were detected α-thalassemia genotypes by amniocentesis or cordocentesis.MCA-PSV was expressed as multiples of the median(MOM).Results:MCA-PSV in the group of fetuses with Hemoglobin Bart's Hydrops Fetalis Syndrome was significantly higher than the fetuses with Hemoglobin H disease,α-thalassemia Trait and the normal fetuses (P0.001).The best cut-off point of MCA-PSV was 1.29 MOM.The sensitivity and the specificity of MCA-PSV1.29 MOM in prediction of Hemoglobin Bart's Hydrops Fetalis Syndrome were 81.25% and 93.62% respectively.The earliest time for MCA-PSV to predict Hemoglobin Bart's Hydrops Fetalis Syndrome was 16 gestational weeks.Conclusion:Measurement of MCA-PSV by Doppler ultrasound can be used as a noninvasive tool to predict Hemoglobin Bart's Hydrops Fetalis Syndrome and reduce unwanted invasive operation." @default.
- W2369968700 created "2016-06-24" @default.
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- W2369968700 date "2010-01-01" @default.
- W2369968700 modified "2023-09-25" @default.
- W2369968700 title "Study of middle cerebral artery peak systolic velocity by Doppler ultrasonography in predicting fetal α-thalassemia" @default.
- W2369968700 hasPublicationYear "2010" @default.
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