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- W2369969855 abstract "Objective:To observe the antiseptic effect of peiminine combined with ampicillin sulbactam in vivo,and try to explore its possible mechanism.Methods:40 SD rats were randomly divided into 4 groups:blank control group,model group,ampicillin sulbactam group(AMP/SBT),ampicillin sulbactam+Peiminine group(AMP/SBT+PM2).In addition to the blank control group,all groups were injected with multi-drug resistant E.coli though caudal vein to cause the rat sepsis model.1h later,drug administration began,AMP/SBT dose:466mg/kg/d,intraperitoneal injection of 1ml,twice daily;PM2 daily dosage of 5.83mg/ kg,administered 2ml once a day.Record the animal mortality,body weight,body temperature,general condition,etc.,white blood cell count and neutrophil percentage,drug susceptibility test.Results:AMP/SBT+PM2 group won the best antibacterial effect,the general situation than the model group,AMP/SBT group is good,lighter pathological damage,higher survival rate(P0.01,P0.01),lower body temperature(P0.05,P0.01),lower white blood cell count(P0.05,P0.01),low neutrophil(P0.01,P0.01).Bacteria elimination rate AMP/SBT+PM2 group,80%,AMP/BT group,30%,the difference was statistically significant (P0.01).Susceptibility test in each group before administration prompted strictly resistant to ampicillin,after administration all blood culture-positive specimens of AMP/SBT+PM2 group turn sensitive.Conclusions:Peiminine combined with ampicillin sulbactam using in vivo is more effective than ampicillin sulbactam alone.It is proven by drug susceptibility test that the effect is achieved by reversal of bacterial resistance." @default.
- W2369969855 created "2016-06-24" @default.
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- W2369969855 date "2010-01-01" @default.
- W2369969855 modified "2023-09-24" @default.
- W2369969855 title "Study on peiminine combined with ampicillin and sulbactam reversing drug-resistant infection in vivo" @default.
- W2369969855 hasPublicationYear "2010" @default.
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