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- W2369976800 abstract "Objective To determine the amount of high energy phosphates and internal ratios various phosphate metabolites in myocardium of normal subjects and patients with myocardial infarction using 31 P MR spectroscopy ( 31 P MRS), and to assess the clinical value of 31 P MRS in patients with myocardial infarction (MI). Methods Fifteen patients (all men, aged 31 66 years, mean 53.8 years) of MI (acute 5, chronic 10) with ejection fraction of less than 46% and 8 healthy volunteers (normal controls) were studied using a 1.5 T Siemens Magneton 63 SP MR imager. The 10 cm diameter surface coil ( 1H and 31 P double tuned surface coil ) was employed. To minimize motion artifacts, the subjects were examined in prone position with chest wall lying just above the surface coil. 31 P MRS study was further conducted in 7 of 15 patients after PTCA and coronary thrombolytic therapy. Results In the control group, the myocardium PCr/β ATP and Pi/PCr ratio were 1.58±0.19 and 0.36±0.17, respectively, while in patients with MI, these parameters were 0.98±0.31 and 1.22±0.66 ( P 0.001). The difference between the control group and MI group was statistically significant. After therapy, these parameters turned out to be 1.21±0.34 and 0.96±0.21 ( P 0.05), respectively, which were significantly different compared with those prior to therapy. Conclusions An investigation using 31 P MRS in MI in Chinese population was first reported. The contents of high energy metabolites and their ratios in myocardium in both normal control and those with MI were studied. Myocardial high energy phosphates were not depleted in human MI. 31 P MRS possesses a great potential in evaluating myocardial viability, effects of reperfusion, and the recovery of myocardial physiologic function after reestablishment of coronary blood flow." @default.
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- W2369976800 date "1999-01-01" @default.
- W2369976800 modified "2023-09-23" @default.
- W2369976800 title "The value of magnetic resonance spectroscopy in diagnosing myocardial infarction" @default.
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