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- W2369979866 abstract "Objective: To investigate the effects of nicotine on 6 OHDA induced degeneration of nigrostriatal dopaminergic neurons in rats. Methods: 6 OHDA was stereoscopically injected to right side of the mesencephic ventral tegmental area (VTA) and substantia nigra pars compacta (SNpc). Nicotine of different dosages was intraperitoneally injected two weeks before or after the operation. Using biochemical techniques, we observed the changes of the free radical and dopamine content in striatum and subatantia migra. Result: Chronic nicotine treatment given 2 weeks uefore 6 OHDA was injected into the brain, the free radical were decreased in substantia nigra and dopamine content in striatum were increased compared to the PD group ( P 0.05). Chronic nicotine treatment given 2 weeks after PD models were successful, the indexes of the group were chang ed compared to the PD group ( P 0.05). Conclusion: Nicotine can protect dopamine neurons of substantia nigra from the damage of 6 OHDA." @default.
- W2369979866 created "2016-06-24" @default.
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- W2369979866 date "2002-01-01" @default.
- W2369979866 modified "2023-09-25" @default.
- W2369979866 title "Effects of nicotine on dopamine and free radical in 6-OHDA-indiced Parkinon's disease." @default.
- W2369979866 hasPublicationYear "2002" @default.
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