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- W2369980373 abstract "Objective To distinguish proliferating infantile hemangioma(IH) and kaporsiform hemangioendothelioma(KHE) by comparing the pathological structure and marker antigen expression.Methods From January 2001 to June 2009,33 paraffin-embedded and fresh samples,21 proliferating IH and 11 KHE,were collected from Nanjing Children's Hospital and Jinling Hospital.Hematoxylin-eosin(HE) staining and transmission electron microscopy(TEM) were used to observe the pathological structure.Immunohistochemical analysis was also performed to investigate the expression of D2-40 and Glut1.Results HE staining revealed that proliferating IH had dense capillary plexus and flat pericytes in the wall of neo capillaries,and that KHE was composed of tumor nodules with slit-like channels in the center and capillaries in the margin.TEM revealed multi-layer basement membrane of neo-capllaries in IH,and slit-like channels and capillaries with thinlayered basement membrane in KHE.There were pericytes in the basement membrane in both.Immunochemistry revealed that the endothelial cells expressed Glut1,but not D2-40 in IH;while D2-40,but not Glut1 in KHE.Conclusion The pathological structure of proliferating IH is obviously different from that of KHE.D2-40 and Glut1 are the reliable marker antigens for differential diagnosis of proliferating IH and KHE." @default.
- W2369980373 created "2016-06-24" @default.
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- W2369980373 date "2010-01-01" @default.
- W2369980373 modified "2023-09-24" @default.
- W2369980373 title "Comparative Study On Pathology of Proliferating Infantile Hemangioma and Kaporsiform Hemangioendothelioma" @default.
- W2369980373 hasPublicationYear "2010" @default.
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