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- W2369993144 abstract "Objective:To compare the efficacy of two graft versus-host disease(GVHD) prophylaxis regimens in unrelated donor hematopoietic stem cell transplantation(URD-HSCT).Method:Forty patients who received URD-HSCT were divided into two groups.Twenty-seven patients received cyclosporine A,mycophenolate mofetile,short-term methotrexate,antithymocyte globulin(ATG) and CD25 monoclonal antibody(mAb) as GVHD prophylaxis regimen.Thirteen patients received cyclosporine A,mycophenolate mofetil,short-term methotrexate and ATG as GVHD prophylaxis regimen.Result:①The recovery time of neutrophil in CD25 mAb group and ATG-group was(14.67±4.08) days and(14.53±3.30) days,respectively(P0.05).The recovery time of platelet in CD25 mAb group and ATG-group was(23.83±11.67)days and(23.33±12.01) days,respectively(P0.05).②The incidence of acute GVHD in CD25 mAb group and ATG-group was 25.9% and 23.1%,respectively(P0.05).The incidence of grade Ⅱ-Ⅳ acute GVHD in CD25 mAb group and ATG-group was 11.1% and 15.3%,respectively(P0.05).The incidence of chronic GVHD in two groups was 29.0% and 0%,respectively(P0.05).The incidence of extensive chronic GVHD in two groups was 11.0% and 0%,respectively(P0.05).③The incidence of relapse in two groups was 25.9% and 23.1%,respectively(P0.05).④The estimated 2 year overall survival in two groups was 48.15% and 61.54%,respectively(P0.05).The estimated 2 year disease free survival in two groups was 44.4% and 53.8%,respectively(P0.05).Conclusion:The combination of cyclosporine A,mycophenolate mofetil,short-term methotrexate and ATG was a preferable GVHD prophylaxis regimen in URD-HSCT." @default.
- W2369993144 created "2016-06-24" @default.
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- W2369993144 date "2011-01-01" @default.
- W2369993144 modified "2023-09-24" @default.
- W2369993144 title "Clinical study on graft versus-host disease prophylaxis regimens in unrelated donor hematopoietic stem cell transplantation" @default.
- W2369993144 hasPublicationYear "2011" @default.
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