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- W2369997503 abstract "Objective To investigate solid-liquid separation and absorption of coenzyme Q10(CoQ10)by millipore filters,chose the best solid-liquid separation condition and study the relationship between particle size and solubility with naked CoQ10 nanocrystals under chosen conditions.Methods The precipitation method was used to prepare CoQ10 nanocrystals.The absorption was researched at different concentrations of ethanol and the solid-liquid separation was performed for both nanocrystals and bulk drugs.The dilution-dissolution method was employed to determine the equilibrium solubility of CoQ10 nanocrystals and bulk drugs in four ethanol-water solvents.The new concept ofinterfacial solubility,Sifwas proposed and the dissolution curves of 87.6 nm CoQ10 nanocrystals and bulk drug were used to study the relationship between particle size and interfacial solubility.Results The absorption order of the drug to millipore filters was 0.05 μm PC,0.22 μm PA,0.05 μm PVDF,0.22 μm PVDF and 0.10 μm PES.The latter three filters had no absorption when the concentration of ethanol was not less than 70%(φ).The optimal solid-liquid separation condition for nanocrystals was 0.22 μm PVDF+0.05 μm PVDF+0.22 μm PVDF,and for bulk drugs was 0.22 μm PVDF+0.22 μm PVDF.The equilibrium solubility of CoQ10 nanocrystals(with particle sizes of 114.8 nm,85.1 nm,77.4 nm and 58.9 nm)and bulk drugs in four ethanol-water solvents were 0.82-0.88,4.40-4.74,16.70-17.43,31.75-33.04 mg·L-1,respectively.Under diluted conditions,the micro difference in interfacial layer between nanocrystals and bulk drug was enlarged and displayed special solublization curves.For nanocrystals,the concentration of the drug quickly increased to a supersaturated state and then decreased gradually to a plateau.While for bulk drug,the concentration of the drug increased gradually to a plateau equal to that of nanocrystals,which demonstrated the same equilibrium solubility.Conclusions The particle size is related tointerfacial solubilityrather thanequilibrium solubility." @default.
- W2369997503 created "2016-06-24" @default.
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- W2369997503 date "2011-01-01" @default.
- W2369997503 modified "2023-09-22" @default.
- W2369997503 title "Equilibrium solubility of naked nanocrystals is not related to particle size" @default.
- W2369997503 hasPublicationYear "2011" @default.
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