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- W2370001030 abstract "Objective To observe the effects of the selectiveβ2-adrenoceptor antagonist ICI118551on cardiac function of heart failure rats.Methods Establishing heart failure rats by abdominal aortic ligation,and the cardiomyocytes were isolated with collagenases.The cardiomyocytes were divided into sham group,HF group,HF+dH 2 O group,HF+ ICI118551 group,and all cells were cultured for 48 hours.Contractile function of cardiomyocytes was measured with motion edge-detection system of single cell at 48 h after culturation.Results Compared to pseudo-operation group,the cardiomyocyte survival rate was significantly reduced(P 0.01).Compared with control group,percentage of basic contraction amplitude under normal condition.Conclusion With the neural and humoral regulations excluded,ICI118551 produces a negative inotropic effect." @default.
- W2370001030 created "2016-06-24" @default.
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- W2370001030 date "2012-01-01" @default.
- W2370001030 modified "2023-09-25" @default.
- W2370001030 title "Effects of ICI118551 on cardiac function of heart failure rats" @default.
- W2370001030 hasPublicationYear "2012" @default.
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