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- W2370024552 abstract "Objective Using pressure-volume conductance catheter system to investigate the effect of chronic pressure-overload on left ventricular(LV)hemodynamics in hypertensive rats.Methods Six-month-old male stroke-prone spontaneously hypertensive rats(SHR-SPs,n=10)and age-matched male Wistar-Kyoto(WKY)rats (n=10)were used.The animals were anaesthetized and a 2F Millar pressure-volume conductance catheter(SPR- 838)was inserted through right carotid artery into LV to measure pressure-volume(P-V)relationship.Results We found that left ventricular end-systolic pressure,left ventrieular end-systolic volume and+dP/dt_(max)were all remarkablely higher in SHR-SPs than those in WKY rats(P0.05).Compared with WKY rats,ejection fraction, stroke volume and cardiac output were decreased in SHR-SPs(P0.05).The slope of left ventricular end systolic pressure-volume relationship was greatly elevated in SHR-SPs.The constant of isovolumeric relaxation(Tau)was prolonged in SHR-SPs(P0.05)and left ventricular end-diastolic pressure and left ventricular end-diastolic volume were significantly increased in SHR-SPs than in WKY rats(P0.05).In addition,-dP/dt_(min),was decreased in SHR-SPs(P0.05).The in vivo P-V loop curve was notably rightward shifted in SHR-SPs.Conclusion These results show that pressure-overload could induce LV diastolic dysfunction,deterioration of systolic perform- ance and partial LV dilation.The pressure-volume conductance catheter system is an useful tool for objective and accurate assessment of cardiac function in rats." @default.
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- W2370024552 date "2008-01-01" @default.
- W2370024552 modified "2023-09-22" @default.
- W2370024552 title "Assessment of Left Ventricular Function in Stroke-Prone Spontaneously Hypertensive Rats by Pressure-Volume Conductance Catheter System" @default.
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