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- W2370036159 abstract "Objective To investigate the concordance between fluorescence in situ hybridization and immunohistochemistry assessment for HER-2 status of patients with invasive breast cancer and to evaluate the association between HER-2 gene amplification and clinicopathological characteristics.Methods Retrospective analysis of 112 cases of patients with invasive breast cancer with HER-2 gene detected by FISH,the FISH findings were compared with IHC test results by analyzing the concordance between two results.The associations between HER-2 gene amplification and other clinicopathological factors such as age,tumor grade,estrogen/progesterone receptor and lymph node status were evaluated using χ2 test.Results HER-2 amplifications by FISH were seen in 57 patients,including 27 IHC(3+) patients(96.4%,27/28 of all(3+) patients),29 IHC(2+) patients(48.3%,29/60 of all(2+) patients),1 IHC(1+) patients(5.3%,1/19 of all(1+) patients) and none IHC(0) negative patient(0,0/5 of all negative cases).The overall coincidence rate of IHC test and FISH was 96%.And the discordance was mainly found in the IHC(2+) group.HER-2 gene amplification was negatively correlated with estrogen/progesterone receptor status and no significant difference was found between HER-2 gene amplification and age,tumor grade,lymph node status.Conclusion For patients with HER-2 IHC(3+,1+,0),FISH can be selected,while the patients with HER-2 IHC(2+) should be verified by FISH to accurately determine the status of the HER-2 gene." @default.
- W2370036159 created "2016-06-24" @default.
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- W2370036159 date "2013-01-01" @default.
- W2370036159 modified "2023-09-26" @default.
- W2370036159 title "Comparison of fluorescence in situ hybridization and immunohistochemistry assessment for HER-2 status in breast cancer and its relationship to clinicopathological characteristics" @default.
- W2370036159 hasPublicationYear "2013" @default.
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