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- W2370043769 abstract "Objective To observe the effect of Tongfeng Suxiaoning(TFSXN) on the hyperuricemia and acute gouty arthritis in different period in rats,and investigate the curative mechanism of TFSXN in the arthritis.Method The 96 SD male rats were randomly divided into three groups as model control group(A),colchicine group(B) and TFSXN group(C),32 rats in each group.The models with hyperuricemia and acute gouty arthritis were induced by uricase inhibitor potassium oxonate injected into abdominal cavity and urate sodium solution into the articular cavity of knee joints;3 hours before and after the establishment of the model,physiological saline and colchicine were filled into intra-gastric in model contrast and colchicines groups,and TFSXN into TFSXN group;Then,the blood,articular fluid and synovium in the joints were obtained from 8 rats in each group in the periods of 6,12,24,36 hours to measure the changes of the serum uric acid,leucocytes in joint fluid and urate sodium crystal.Result Compared with A,1.TFSXN decreased the level of serum uric acid(P0.01);2.TFSXN promoted the clearing of urate sodium crystal(P0.01);and compared with C,3.TFSXN inhibited leucocytes effusion in the joint fluid,relieved and improved the severity of synovial inflammation(P0.05,P0.05).Conclusion TFSXN has the curative effect for the hyperuricemia and acute gouty arthritis in rats." @default.
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- W2370043769 date "2006-01-01" @default.
- W2370043769 modified "2023-09-25" @default.
- W2370043769 title "Experimental Study of Tongfeng Suxiaoning on Acute Gouty Arthritis in Rats" @default.
- W2370043769 hasPublicationYear "2006" @default.
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