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- W2370046045 abstract "Objective To investigate the effect of the expression of calicitonin gene-related peptide(CGRP)in spinal cord upon the axonal regeneration of motor neurons after selective brachial plexus injury.Methods Twenty-nine rats were divided into 4 groups:three injury groups and control group.Three kinds of selective brachial plexus injury models were established by right C7 anterior root avulsion(group A),the right anterior root avulsion of 7th cervical nerve plus right posterior root block from the 5 th cervical nerve to first thoracic nerve(group B),right C7 anterior root avulsion plus hemi-transect between C5 and C6 segment of spinal cord(group C).Two weeks after the operation,the expression of CGRP mRNA of C7 anterior and posterior horn in right side was detected by real-time quantitative PCR with SYBR Green 1 fluorescence.Results In control group,the expression of CGRP mRNA in anterior and posterior horn was low,and it was relatively higher in anterior horn than in posterior horn.Compared with control group,CGRP mRNA expression increased in anterior horn in three injury groups,especially in group C,while it decreased in posterior horn.Conclusion The change of CGRP expression is a response of peculiar protein in nerve regeneration after brachial plexus injury,paticularly,the high expression of CGRP in anterior horn plays an important role in the axonal regeneration.CGRP in anterior and posterior horn may have different effects." @default.
- W2370046045 created "2016-06-24" @default.
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- W2370046045 date "2010-01-01" @default.
- W2370046045 modified "2023-09-25" @default.
- W2370046045 title "Expression of CGRP mRNA in rat spinal cord after selective brachial plexus injury" @default.
- W2370046045 hasPublicationYear "2010" @default.
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