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- W2370066036 abstract "Objective To study the effect of Buying Huanwu Tang(Decoction Invigorating Yang for Recuperation) on expression of NMDA receptors and LTPin hippocampal CAl area of rats with vascular dementia(VaD) and its mechanism.Methods One hundred and forty-four SD rats were randomly divided into sham operation group,VaD model group,nimodipine group,and Buying Huanwu Tang group(36 in each group).A rat VaD model was established by 4-vessel occlusion. Learning and memory of the rats were assessed by Morris water maze testing and recording the LTP in hippocampal CA3-CA1 area.Expressions of NR1,NR2A and NR2B proteins in hippocampal neurons were detected by immunohistochemistry,Western blot and RT-PCR,respectively. Results The escaping latency time(s) was longer,the average number of cross-platform exploration was less,the expression levels of NR1,NR2A,NR2B proteins and mRNA and LTP in hippocampal CA1 area were significantly lower in VaD model group than in sham operation group (P0.05).The learning and memory scores were significantly higher in Buying Huanwu Tang group and nimodipine group than in VaD model group(P0.05).No significant difference was found in learning and memory scores between Buying Huanwu Tang group and nimodipine group. Conclusion Buying Huanwu Tang can improve the learning and memory of rats by up-regulating the expression of NR1,NR2A,NR2B and LTP in hippocampal CA1 area." @default.
- W2370066036 created "2016-06-24" @default.
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- W2370066036 date "2012-01-01" @default.
- W2370066036 modified "2023-09-23" @default.
- W2370066036 title "Effect of Buying Huanwu Tang on learning,memory and expression of NMDA receptors in hippocampus of rats with vascular dementia" @default.
- W2370066036 hasPublicationYear "2012" @default.
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