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- W2370104076 abstract "OBJECTIVE:To investigate the expression of CRM1 in osteosarcoma and normal cartilage tissues. METHODS:Western blot was used to investigae the expression of CRM1 in 57 cases of osteosarcoma compared with 5 cases of normal tissues. RESULTS:The expression of CRM1 was significantly higher in osteosarcoma than that in normal tissues. The high expression of CRM1 was significantly associated with the increased serum level of alkaline phosphatase (P=0.001) but did not associate with that of lactate dehydrogenase (P=0.065). In univariate analysis,a significant association between CRM1 expression and tumor size (P=0.014) as well as histological grade (P=0.003) was observed,while high CRM1 expression was not correlated with the other clinicopathological parameters. In Kaplan-Meier survival analysis,the high CRM1 expression was a significant prognostic indicator for progression-free survival (P=0.016) as well as overall survival (P=0.008). Multivariate analysis demonstrated that the expression of CRM1 was an independent prognostic parameter for longer overall survival (95%CI,1.27-5.39).CONCLUSION:The prognosis of osteosarcoma is associated with the high expression of CRM1." @default.
- W2370104076 created "2016-06-24" @default.
- W2370104076 creator A5018773616 @default.
- W2370104076 date "2009-01-01" @default.
- W2370104076 modified "2023-09-28" @default.
- W2370104076 title "High expression of CRM1 as a prognostic parameter in human osteosarcoma tissues" @default.
- W2370104076 hasPublicationYear "2009" @default.
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