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- W2370109238 abstract "Objective: To investigate the effects of Hydroxy Safflor yellow A(HSYA) on the protein and mRNA expression of KDR,HIF-1α and protein expression of VEGF in serum or transplantation tumor of gastric adenocarcinoma cell line BGC-823 in nude mice.Methods: The BGC-823 cells was subcutaneouly injected into the right anterior armpit of BALB/C nu/nu nude mice and established the animal model of transplantation tumor.The experimental groups were treated with HSYA at concentration of 0.056g/L and 0.028g/L and cyclophosphamide at 2g/L,or with physiologic saline.The tumor inhibitory effect was observed,and the protein expression of transplantation tumor's VEGF,HIF-1α and serum VEGF were detected by enzyme linked immunosorbent assay,and the KDR protein expression was detected by Western blotting.The mRNA expression of KDR and HIF-1α in transplantation tumor were detected by real time-fluorescent quantitation PCR respectively.Results: The IR in the group with HSYA at the concentration of 0.028g/L is higher than in the group with normal sodium.The protein expression of VEGF,phosphorylated KDR and HIF-1α has significant difference after treatment with HSYA at the concentration of 0.028g/L as compared with physiologic saline-treated group(P0.05,P0.01).The mRNA expression of KDR in 0.028g/L HSYA group is less obviously than in the physiologic saline-treated group(P0.05).Conclusion: The possible mechanism of HSYA in given concentration to antagonize tumor angiogenesis may be related with inhibiting the protein expression of VEGF,and HIF-1α and weakening the phosphorylation of KDR protein and its gene expression to inhibit the activation of endotheliocyte and impede the inducion of tumor oxygen-poor microenvironment to angiogenesis." @default.
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- W2370109238 date "2012-01-01" @default.
- W2370109238 modified "2023-09-23" @default.
- W2370109238 title "Effects of HSYA on protein and mRNA expression of KDR,HIF-1α and protein expression of VEGF in nude mice with BGC-823 transplantation tumor" @default.
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