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- W2370109711 abstract "Objective:The purpose of this study is to explore the role of active UC patients' peripheral blood mononuclear cells RORC and Foxp3 mRNA and related cytokines and different concentrations of baicalin.Methods:Q-PCR detection of transcription factor RORC and Foxp3 mRNA expression were detected by ELISA in serum IFN-r,IL-6,IL-10,TGF-β1 levels and the indicators were detected in vitro intervened by baicalin.Results:The study found that IFN-r,IL-4,IL-5,IL-10 and TGF-β1 and those of IBS-D group and the healthy control group were increased in varying degrees,IL-6 compared with that in IBS-D and healthy control groups was slightly reduced.In vitro,different solubilities of baicalin caused IFN-r,IL-5 and IL-6 significantly reduced and IL-4 and IL-10 increased,20 μmol and 40μmol were more obvious.UC patients ' RORC and Foxp3mRNA were significantly higher compared with healthy controls and IBS-D group,and the difference was significant(P 0.05).Baicalin intervention in vitro with concentration of 40μmol can significantly reduce RORC,Foxp3 and RORγt / FOXP3,indirectly regulate the balance of the Th17 / Treg differentiation.Conclusion:The high concentration of baicalin intervention has more obvious role on reducing Foxp3 and RORγt / FOXP3 ratio,and indirectly regulates the Th17 / Treg differentiation balance.Baicalin,as one of the important components of HQT,may regulate the immune balance and ease the ulcerative colon inflammation reaction,providing a theoretical basis for in-depth study of the pathogenesis of UC and the development of new drugs." @default.
- W2370109711 created "2016-06-24" @default.
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- W2370109711 date "2014-01-01" @default.
- W2370109711 modified "2023-09-25" @default.
- W2370109711 title "Changes of Peripheral Blood RORC and Foxp3 Mrna Expression Levels of Ulcerative Colitis Patients and Intervention Effect of Baicalin" @default.
- W2370109711 hasPublicationYear "2014" @default.
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