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- W2370111963 abstract "In this paper, content of cytochrome P450 and activities of CYP2B1and CYP2E1 in liver of male SD rats subjected to intraperitioned injection of MMC or γ?ray irradiation, were studied. Groups No.1-3 of the rats were injected with MMC of 1mg / kg d for 1 , 3 or 6 days. Group No.4-6 of the rats were treated respectively with one injection of MMC at 3 mg / kg, 3 Gy of 137Cs γ?ray irradiation, or a combination of the MMC injection a t 3 mg / kg after 3 Gy γ?ray irradiation. Biological measurements of the experimental groups were compared to blank groups and solvent control groups. The results showed that for the group administered on the first day with MMC at 1 mg / kg, the CYP2E1 activity increased (p 0.01), whereas the P450 content and the CYP2B1 activity did not change. For the group injected with MMC at 1 mg / kg d for 3 d or 6 d, no significant changes were found in the P450 content and the activities of CYP2B1and CYP2E1. With the 3 mg / kg MMC group, the CYP2E1 activity increased significantly ( p 0.01), but no marked effects were observed in the P450 content and the CYP2B1 activity. The CYP2E1 activity deceased in the 3 Gy irradiated group ( p 0.05), with no effect on the P450 content and the CYP2B1 activity. There was no interaction between 3 mg / kg MMC and 3Gy irradiation. The results indicated that MMC induced the CYP2E1 activity, yet repeated treatment with MMC might cause the rats to gain some resistance to it, in addition, 3 Gy γay?irradiation inhibited the CYP2E1activity, but combined treatments of the 3 Gy irradiation and MMC injec- tion showed no significant effect on the P450 content and the CYP2B1 activity in vivo." @default.
- W2370111963 created "2016-06-24" @default.
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- W2370111963 date "2005-01-01" @default.
- W2370111963 modified "2023-09-23" @default.
- W2370111963 title "Effects of mitomycin(MMC) and γ-ray irradiation on cytochome p450 content and activities of CYP2B1and CYP2E1 in rats" @default.
- W2370111963 hasPublicationYear "2005" @default.
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