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- W2370136195 abstract "Objective To evaluate the application of optical coherence tomography (OCT) in the rat retinal light damage. Methods Albino Sprague-Dawley (SD) rats (5-8 weeks of age) were exposed to 1 000-1 400 lux of diffuse, cool, white, fluorescent light for 2, 5, and 7 d. OCT image analysis and histological measurements of the retinal thickness were performed. Animals were then sacrificed and the measured results were compared with those by histological examination. Results The sensory retinal thickness of the retina in the rats thinned progressively as the retinal degeneration was in progress. The sensory retinal thickness measured by OCT [the corresponding thickness was (179.11±12.01)μm, (159.27±12.81)μm, and (133.67±11.43)μm, respectively] was well correlated with that measured by histology [the sensory retinal thickness after exposure to the light for 2, 5, and 7 d was (144.26±9.36)μm, (116.16±11.24)μm, and (94.27±10.68)μm, respectively] (r= 0.995, P0.01). Conclusion OCT imaging technique, a simple, liable, and non-invasive method, can monitor the progressive structural changes of retinal degeneration in rats." @default.
- W2370136195 created "2016-06-24" @default.
- W2370136195 creator A5090849806 @default.
- W2370136195 date "2004-01-01" @default.
- W2370136195 modified "2023-09-22" @default.
- W2370136195 title "Application of optical coherence tomography technique in the research of rat retinal light damage" @default.
- W2370136195 hasPublicationYear "2004" @default.
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