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- W2370154082 abstract "Objective To investigate the role of 17β-estradiol in the reendothelialization after carotid injury by mobilization of bone marrow-derived endothelial progenitor cells (EPCs). Methods Carotid injury was induced in ovariectomized mice. Physiological dose , infra-physiological dose of 17β-estradiol or placebo was given before and after carotid injury. The EPCs number was determined by flow cytometry directly (CD34+/CD133+),the extent of reendothelialization was measured by area after injection of evans blue dye at 1 week following carotid injury . Results The number of EPCs in the group receiving 17β-estradiol(physiological dose or infra-physiological dose) was increased significantly than that in the group receiving placebo. The area of carotid injury in the former was smaller than that in the latter. No significant difference was found between the physiological dose group and the infra-physiological dose group. Conclusion The physiological dose or infra-physiological dose of 17β-estradiol can similarly accelerate reendothelialization via promoting mobilization of EPC after carotid injury. The role of 17β-estradiol in carotid injury shows no significant difference between physiological dose or infra-physiological dose." @default.
- W2370154082 created "2016-06-24" @default.
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- W2370154082 date "2010-01-01" @default.
- W2370154082 modified "2023-09-28" @default.
- W2370154082 title "Role of 17β-estradiol in Repair of Carotid Artery Injury" @default.
- W2370154082 hasPublicationYear "2010" @default.
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