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- W2370172783 abstract "Objective To explore the effect of TSA in the Modulation of HIF 1α and VEGF on the model of human adenocarcinoma in nude mice .Methods Nude mice model bearing lung carcinoma was established using human adenocarcinoma A549 cell strains .Trichostatin A(TSA) and 0.9% saline(NS) were injected into the tumor. The volume and the average weight of neoplasia were detected;the expression of HIF 1α and VEGF were examined by immunohistochemical stain and in situ hybridization.Results The difference of the average volume and the average weight of neoplasia were statistical significance between TSA treatment and NS treatment ( P 0.05 ).The expression of HIF 1α and VEGF of the TSA treatment were lower than the NS treatment ( P 0.05 ).Conclusion TSA may depress the expression of HIF 1α and VEGF in tumor constitution. These studies show that TSA is useful for adenocarcinoma in nude mice." @default.
- W2370172783 created "2016-06-24" @default.
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- W2370172783 date "2004-01-01" @default.
- W2370172783 modified "2023-09-23" @default.
- W2370172783 title "The Study of TSA in the Modulation of HIF-1α and VEGF on the Model of Human Adenocarcinoma in Nude Mice" @default.
- W2370172783 hasPublicationYear "2004" @default.
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