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- W2370181459 abstract "Objective To evaluate the effect of cetylpyridinium chloride(CYC)eye drop on fungal keratitis of guinea pig,and provide the experimental basis for developing the ideal anti-fungus drug.Methods Eighty healthy guinea pig were used to establish the experimental fungal keratitis model by improved methods,60 cases with the similar infection degree were selected and randomly divided into five groups,group A:control group;group B:fluconazole group;group C:natamycin group;group D:CYC eye drop-1 group;group E:CYC eye drop-2 group.Group B,C,D,E received fluconazole,natamycin and CYC eye drops,respectively.The corneal histological changes,the fungal spore and hypha in each group were observed by slit lamp and light microscope,the clinical scoring for fungal keratitis was made,and the curative effect of CYC on fungal keratitis was compared.Results The clinical scoring at 10 days after opened the eyelid in group A,B,C,D,E were 6.667±1.367,4.833±1.472,3.167±1.330,1.500±1.225 and 0.667±0.817,respectively.The scoring of CYC group were obviously lower than that of other groups,there was statistical difference(P0.05).At 8 days after opened the eyelid,the ulcer were disappeared and the corneal surface were smooth and glossy,no fungal spore and hypha was seen in group D and group E,but in other three groups many sporesand hypha were surrounded the inflammatory necrosis.Conclusion By splitting eliminates the epithelia corneal,suturing the eyelid,dropping colony to eye,the experimental fungal keratitis model can be established successfully.CYC eye drop is superior to fluconazole and natamycin on treating the experimental keratomycosis of guinea pig." @default.
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- W2370181459 date "2010-01-01" @default.
- W2370181459 modified "2023-09-23" @default.
- W2370181459 title "Cetylpyridinium chloride in treatment of fungal keratitis of guinea pig" @default.
- W2370181459 hasPublicationYear "2010" @default.
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