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- W2370184710 abstract "Objective To explore the feasibility of using paclitaxel (PTX)-loaded superparamagnetic nanoparticles for the treatment of glioma in magnetic targeted chemotherapy. Methods Superparamagnetic paclitaxel nanoparticles were made from modified chitosan, Fe_3O_4 ferromagnetic fluid, cholestorol and paclitaxel. They were tested with transmission electron microscope (TEM) and vibration specimen magnetometer to observe their morphology and magnetism. They were injected into rats through caudal vein and a 0.5T magnetic field was placed across the rats' head in magnetic targeting group. The paclitaxel concentration in rats' brain was tested. The distribution of superparamagnetic paclitaxel nanoparticles was stained by Prussion staining and observed by light microscope. Results The paclitaxel nanoparticles were superparamagnetic and elevated local drug concentration significantly in magnetic targeting group compared with non-magnetic targeting group and control group (P0.05, for all). It enhanced the drug concentration for 5-30 times and prolonged the high drug concentraion for more than 16 hours. Microscopic observation found that superparamagnetic paclitaxel nanoparticles concentrated in cortex microvessels and entered neurons by penetrating the blood-brain barrier (BBB). Conclusion Superparamagnetic paclitaxel nanoparticles may improve the local drug concentration in brain and enter neurons under magnetic targeted chemotherapy, and develop the drug action." @default.
- W2370184710 created "2016-06-24" @default.
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- W2370184710 date "2009-01-01" @default.
- W2370184710 modified "2023-09-25" @default.
- W2370184710 title "Study on magnetic targeted chemotherapy of superparamagnetic paclitaxel nanoparticles to central nervous system tumor" @default.
- W2370184710 hasPublicationYear "2009" @default.
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