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- W2370189521 abstract "Objective: To investigate the relationship between the mutation of ABCB4 gene exon 12 and intrahepatic cholestasis of pregnancy(ICP).Methods: Genomic DNA was extracted from peripheral blood of 31 ICP patients.Using polymerase chain reaction(PCR),the ABCB4 gene exon 12 was amplified.The PCR products were then sequenced as to detect the mutation.Results: The target band of ABCB4 gene exon 12 were found in all 31 cases with ICP.No deletion were detected.20 patients were selected randomly from 31 ICP patients for DNA sequencing.No mutations of ABCB4 gene exon 12 were identified.Conclusion: The finding suggests that there are no or little relations between the mutation of ABCB4 gene exon 12 and the ICP patients in South Anhui province of China.Other mutation hot spots of ABCB4 gene may exit.Further enlargement of sample size and investigation of other ABCB4 gene mutation hot spots are needed to testify the relationship between the mutation of ABCB4 gene and the pathogenesis of ICP." @default.
- W2370189521 created "2016-06-24" @default.
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- W2370189521 date "2007-01-01" @default.
- W2370189521 modified "2023-09-23" @default.
- W2370189521 title "Relationship between the mutation of ABCB4 gene exon 12 and intrahepatic cholestasis of pregnancy." @default.
- W2370189521 hasPublicationYear "2007" @default.
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