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- W2370224507 abstract "Aim To observe the effect of rosuvastatin on methylation level and expression of Bcl-2 in aorta of rats with hyperhomocysteinamia.Method Thirty-three healthy five-week-old Wistar male rats,weighting(150±10)g,were randomly divided into the control,Hhcy and rosuvastatin groups(n=11,each).The control was given normal food. The Hhcy was given normal food and methionine [1g/(kg·d),orally].The rosuvastatin was given normal food,methionine [1 g/(kg·d),orally] and rosuvastatin[10 mg/(kg·d),orally].Sixteen weeks later,rats were sacrificed and blood were taken from its heart.The homocysteine in serum was detected with automatic biochemistry analyzer.Methylation special PCR and nested PCR were used to examine methylation level of Bcl-2.Real-time PCR was used to detect mRNA expression.Immunohistochemistry and Western blot were used to detect protein expression.Results Sixteen weeks later,the homocysteine in serum of Hhcy group were significantly higher than the control group(P0.01).Rosuvastatin can decrease homocysteine concentration(P0.05).The Hhcy group Bcl-2 promoter region was demethylation,Bcl-2 mRNA and protein expression increased compared to the control(P0.05).the rosuvastatin group Bcl-2 promoter region was hyermethylation,Bcl-2 mRNA and protein expression decreased compared to the Hhcy group(P 0.05).Conclusion Rosuvastatin can prevent demetylation of aorta in rats with hyperhomocysteinamia and down-regulate Bcl-2 expression,which may be one mechanism of its anti-atherosclerosis effect." @default.
- W2370224507 created "2016-06-24" @default.
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- W2370224507 date "2013-01-01" @default.
- W2370224507 modified "2023-09-25" @default.
- W2370224507 title "Rosuvastatin Affect Bcl-2 Methylation in Aorta of Rats with Hyperhomocysteinamia" @default.
- W2370224507 hasPublicationYear "2013" @default.
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