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- W2370232456 abstract "Objective To observe the protective effects of allitridi(Alt) and puerariae flos essence(PFE) on murine hepatosis induced by paracetamol (acetaminophen,Par or APAP).Method The liver injury model induced by paracetamol was established in mice.The animals were divided in four groups which respectively treated by normal saline(control),paracetamol(Par),Par+Alt(according to dosage redivided in 3 subgroups-10,20 and 30mg/kg) and Par+PFE.Then,the activity of asparate aminotransferase(AST) and glutathione s transferase (GST) in serum as well as the contents of MDA and glutathione (GSH) in liver homogenate were tested in mice of all groups.Results Alt obviously inhibited either the increment of serum AST,GST and the hepatic MDA content or the exhaustion of hepatic GSH in Par treated mice (all P0.01).Its inhibition effect on serum GST activity and hepatic GSH descent were dose depended strongly.PFE can also inhibit the increment of serum AST?GST and hepatic MDA,but showed no protective effect on exhaustion of murine hepatic GSH induced by Paracetamol.Conclusion The low dosage of ALT(10mg/kg) can protect murine liver from being injuried by Par.And proper increment of dose of Alt can foster the recovery of murine hepatic function in all the aspect in Par treated mice.PFE can also produce protective effect on murine Par induced hepatosis,which may be inferior to Alt." @default.
- W2370232456 created "2016-06-24" @default.
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- W2370232456 date "2001-01-01" @default.
- W2370232456 modified "2023-10-16" @default.
- W2370232456 title "Protective Effects of Allitridi and Puerariae Flos Essence on Mice Hepatosis Induced by Paracetamol" @default.
- W2370232456 hasPublicationYear "2001" @default.
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