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- W2370242402 abstract "Objective To clarify the change status of HBV DNA loads and hepatitis B virus e system status in different fibrosis stages and hepatocellular carcinoma (HCC) on the natural history of chronic hepatitis B. Methods HBV DNA loads and hepatitis B virus e system status was detected by enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR).Results The ages of chronic hepatitis B in fibrosis stages Ⅰ,Ⅱ, Ⅲ,Ⅳ and HCC were 27.1±7.8, 29.3±7.1, 35.5±7.4, 39.1±9.3 and 50.8±9.6 years old, respectively. The positive rates of HBeAg in fibrosis stages Ⅰ,Ⅱ,Ⅲ,Ⅳ and HCC were 80%(20/25), 70.9%(22/31), 47.8%(11/23), 25%(7/28) and 17.5%(11/63); on the contrary, the positive rates of anti-HBe were 8%(2/25), 16.1%(5/31), 30.4%(7/23), 53.6%(15/28) and 71.4%(45/63); moreover, HBV DNA loads were 2.3×10~7±0.2× 10~2,7.1×10~6±1.2×10~2, 5.7×10~5±1.9×10~2, 1.2×10~5+0.7×10~2 and 4.7×10~4±4.1×10~2(copies/ml), respectively. There were differences of ages, the positive rates of HBeAg and anti-HBe as well as HBV DNA loads among chronic hepatitis B fibrosis stages Ⅰ,Ⅱ,Ⅲ,Ⅳ and HCC.Conclusion These results suggest that the ages of patients are gradually increased to follow the development of chronic hepatitis B fibrosis stage from I to IV and some patients of HCC. On the contrary, the positive rates of anti-HBe increase gradually, which maybe related with long-term human immune pressures, HBV pre-core mutation or and basic core promoter double mutations occurred on some patients.It appears that aggravated liver fibrosis leads to the decreases of hepatic parenchyma cells step by step, which associate with ongoing lessened HBV copy sites." @default.
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- W2370242402 date "2006-01-01" @default.
- W2370242402 modified "2023-09-25" @default.
- W2370242402 title "HBV DNA loads and hepatitis B virus e system status in different fibrosis stages and hepatocellular carcinoma on the natural history of chronic hepatitis B" @default.
- W2370242402 hasPublicationYear "2006" @default.
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