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- W2370243205 abstract "Objective:To investigate the immunoregulatory mechanism of CD4+CD25+regulatory T cells during the early phase of P.yoelii infection.Methods:After splenocytes from BALB/c mice infected by i.p. injection of P.yoelii 17XL parasitized erythrocytes culture with anti-CD25 mAb or anti-CTLA-4 mAb, the levels of IL-10, IFN-γ and TGF-β1 in supernatants were measured by ELISA kits.Results:After culture with anti-CTLA-4 mAb, the levels of IL-10 in spleen supernatants decreased significantly, however, the levels of IFN-γ and TGF-β1 were unchanged; after culture with anti-CD25 mAb, the levels of IL-10, IFN-γ and TGF-β1 were unchanged compared to the blank group, but the levels of IL-10 showed a decreasing tendency.Conclusion:During the early phase of P.yoelii infection, IL-10 may be a crucial cytokine for mediating immunoregulatory effect of CD4+CD25+regulatory T cells, and it is likely CD4+CD25+regulatory T cells exert immunosuppressive action via CTLA-4." @default.
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- W2370243205 date "2007-01-01" @default.
- W2370243205 modified "2023-09-25" @default.
- W2370243205 title "Research on the immunoregulatory mechanism of CD4~+CD25~+ regulatory T cells during the early phase of Plasmodium yoelii infection" @default.
- W2370243205 hasPublicationYear "2007" @default.
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