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- W2370247895 abstract "【Objective】To study the mechanism of Chinese herbal drugs curcumin on human hepatocarcinoma HepG2 cell and the influence to the vegetative cycle of HepG2. 【Methods】Cultured human hepatocarcinoma HepG2 cell in vitro and stimulated it with vary concentration of curcumin (0.5, 1.0, 2.0, 4.0, 8.0 and 16.0 μmol/L) for 24, 36 and 48 hours. MTT and trypan blue staining were carried out to detect the influence of curcumin to HepG2 cell multiplication and draw the cell growth curve, the cell vegetative cycle was detected by flow cytometic analysis.【Results】Vary concentration of curcumin has a obviously inhibitory action on the growth of HepG2 cell by MTT , there has a statistical significance with the concentration of 2.0μmol/L curcumin to the control group after 24 hours and the group of 16.0 μmol/L curcumin has a stronger inhibition (54.78±2.35)% to the HepG2 cell after 48 hours. There has a dose and time effect between the cell survival ratio and the concentration of curcumin by trypan blue staining. 8.0 μmol/L curcumin has induced HepG2 cell to apoptosis and has an apparent blocking effect on the S period of HepG2 by FCM. 【Conclusions】Curcumin can block the growth of human hepatocarcinoma HepG2 cell in vitro and has induced the cell to apoptosis." @default.
- W2370247895 created "2016-06-24" @default.
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- W2370247895 date "2009-01-01" @default.
- W2370247895 modified "2023-09-23" @default.
- W2370247895 title "The studies on apoptosis of human hepatocarcinoma cell line HepG2 induced by curcumin and the influence to the cell vegetative cycle" @default.
- W2370247895 hasPublicationYear "2009" @default.
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