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- W2370251195 abstract "Aim To explore the effect of gastrin17 on expression of β-catenin/Tcf-4 pathway in colonic carcinoma cell line——Colo320WT.Methods Colo-320WT cells were treated with 10-8 mol·L-1 gastrin17 in time-dependent way(0、1、6、12、24、48 h),while treated with 10-6 mol·L-1 L365,260(gastrin17 receptor blocker) for 30 minutes and treated with gastrin17 again for 12 h. The expression levels of β-catenin in TX-100 solution fraction(cytoplasmic) and TX-100 insolution fraction(cytoskeleton bound) of Colo320WT cells, and the expression levels of β-catenin/Tcf-4 complex were detected by coimmunoprecipation and Western blot. The expression levels of c-Myc and cyclinD1 were assayed by Western blot.Results Expression levels of β-catenin in TX-100 solution fraction were decreased apparently, but increased again by L365,260 blocking. Expression levels of β-catenin in TX-100 insolution fraction were on the contrary. Expression levels of β-catenin/Tcf-4 complex increased apparently.Expression levels of c-Myc and cyclinD1 in Colo320WT treated by gastrin17 were higher markedly than those of Colo320WT untreated and treated by L365,260.Conclusions Gastrin17 interacted with CCK-2R and effected significantly distribution of β-catenin in Colo320WT and activated β-catenin/Tcf-4 pathway which led to c-Myc and cyclinD1 high expression,the way gastrin17 decreased cell-cell cohesion and increased tumor cells invasion and metastasis further." @default.
- W2370251195 created "2016-06-24" @default.
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- W2370251195 date "2008-01-01" @default.
- W2370251195 modified "2023-09-26" @default.
- W2370251195 title "Effect of gastrin on expression of β-catenin /Tcf-4 pathway in Colo320WT cells" @default.
- W2370251195 hasPublicationYear "2008" @default.
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