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- W2370252723 abstract "Objective: To investigate dynamic change of Gαq/11 concentration in the spleen during acute lung injury(ALI).Methods: 40 Wistar rats were randomly divided into control group(C group) and experimental groups(OA groups) which were established models by intravenous oleic acid.OA groups included 4 groups: OA30 min,OA60 min,OA90 min,and OA120 min.Gαq/11 concentration in spleen was measured by Western blot.SOD activity and MDA content of plasma and spleen were assessed.Results: Compared with C group,With time passing,Gαq/11 concentration of OA groups(except OA30 min group) obviously increased(P0.05 or 0.01),SOD activity significantly decreased(P0.01) and MDA content increased(P0.05 or 0.01) in plasma and spleen.PaO_2、MAP of OA groups were lower than C group.Conclusions: Up regulation of the expression of Gαq/11 may play a role in the spleen injury during ALI.Change of signal transduction transmited by Gαq/11 may take part in the development of ALI." @default.
- W2370252723 created "2016-06-24" @default.
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- W2370252723 date "2006-01-01" @default.
- W2370252723 modified "2023-09-25" @default.
- W2370252723 title "The dynamic change of Gαq/11 concentration in the spleen during ALI" @default.
- W2370252723 hasPublicationYear "2006" @default.
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