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- W2370255024 abstract "Objective:To study the effect of arsenic trioxide(As2O3) on nucleic acid biosynthesis and apoptosis of melanoma B16 cells.Methods:The nucleic acid biosynthesis in melanoma B16 cells were detected by incorporation of 3H-TdR and 3H-UdR into DNA and RNA,respectively.Apoptosis and necrosis in B 16 cells were analyzed by flow cytomertry.Results:As treated with different doses of As2O3 in B 16 cells the rates of inhibition and apoptosis and necrosis have both dose-dependent and time-dependent manner(P 0.01).Conclusions:As2O3 can inhibit nucleic acid biosynthesis and induce apoptosis and necrosis in melanoma B 16 cells.The assay showed a dose-response and time-response relationship for inhibition of nucleic acid biosynthesis and apoptosis in B 16 cells by As2O3.The inhibition was enhanced with the increase of As2O3 concentration and prolong of co-culture time." @default.
- W2370255024 created "2016-06-24" @default.
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- W2370255024 date "2005-01-01" @default.
- W2370255024 modified "2023-09-23" @default.
- W2370255024 title "Effects of arsenic trioxide on nucleic acid biosynthesis and apoptosis of melanoma B_(16) cells" @default.
- W2370255024 hasPublicationYear "2005" @default.
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