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- W2370259812 abstract "Objective:To investigate the effects of Allitridin on the expression of Th1/Th2 cytokines of spleen cells in mice infected by murine cytomegalovirus (MCMV) and its role in anti cytomegalovirus mechanisms.Method:A BALB/c mice model system of MCMV infection was established.The MCMV model group were allocated randomly into Allitridin treated group and placebo controlled group. The same dose (25 mg·kg -1 /d) and regimen of Allitridin began to be used in treated group at the 48 h after virus infection. The same volum of saline solution was injected in placebo controlled mice.The normal group were allocated randomly into Allitridin injected group and blank controlled group,25 mg·kg -1 /d of Allitridin was used. The same volum of saline solution was injected in blank controlled group . The expression levels of Th1 cytokine IL 2, IFNγ and Th2 cytokine IL 4, IL 10 in supernatant of spleen cell culture were measured by ELISA.Result:MCMV infection could markedly down regulate the expression of IL 2, significantly up regulate the expression of IL 10 of spleen cells in mice. Allitridin could induce increased expression of Th1 cytokine IL 2 and IFNγ significantly(P0.01),decreased expression of Th2 cytokine IL 10 markedly (P0.01).Concluion:Allitridin could increase the expression of Th1 cytokine IL 2 and IFNγ,and inhibit the expression of Th2 cytokine IL 10 in normal and MCMV infected mice, indicating a Th1 dominant state which be helpful for clearance of cytomegalovirus (CMV) in host." @default.
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- W2370259812 date "2004-01-01" @default.
- W2370259812 modified "2023-09-27" @default.
- W2370259812 title "Effects of Allitridin on the Expression of Th1/Th2 Cytokinesof Spleen Cells in Mice Infected by Murine Cytomegalovirus" @default.
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