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- W2370266471 abstract "Objective To investigate the effects of Shuanghuqinggan granule on serum levels of TNF-α,IL-6 and IL-10 in hepatic fibrosis induced by carbon tetrachloride in rats.Methods 60 Sprague-Dawley rats were divided into 6 groups,including normal control group(A),model group(B),Shuanghu qinggan granule low(C1),medium(C2),high(C3) dose group and silymarin contrast group(D).The rats of B,C1,C2,C3 and D were subcutaneously injected by carbon tetrachloride twice a week for 8 weeks.The rats of C1,C2,C3 were administered with Shuanghuqinggan granule at a dose of 5 g/kg body weight(C3),2.5 g/kg(C2) and 1.2 g/kg(C1) for 8 weeks.The rats of D were administered with silymarin at a dose of 50 mg/kg body weight.The changes of serum levels of TNF-α,IL-6 and IL-10 were measured with ELISA.Results Compared with those of group B,the serum levels of TNF-α and IL-6 were significantly decreased in group A,C1,C2,C3 and D(P0.05).Compared with those of group B,the serum levels of IL-10 were significantly increased in group A,C1,C2,C3 and D(P0.05).Conclusion Shuanghuqinggan granule can reduce hepatic fibrosis induced by carbon tetrachloride in rats and its mechanisms maybe involve in TNF-α,IL-6 and IL-10." @default.
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- W2370266471 date "2009-01-01" @default.
- W2370266471 modified "2023-09-23" @default.
- W2370266471 title "Effects of Shuanghuqinggan granule on serum levels of TNF-α,IL-6 and IL-10 in hepatic fibrosis induced by carbon tetrachloride in rats" @default.
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