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- W2370274271 abstract "Objective To investigate the effect of Emodin on the secretion of MCP-1 in peripheral blood mononuclear cells (PBMCs) of patients with diabetic nephropathy.Methods Thirty-two patients of diabetic nephropathy treated with insulin and 24 healthy control were studied. PBMCs were isolated by density gradient centrifugation with Ficoll-Paque and divided into four groups. The effect of Emodin with different density(0、10、50 and 100(g/ml) on MCP-1 secretion in peripheral blood mononuclear cells of patients with diabetic nephropathy which was examined by ELISA were observed. Results The level of MCP-1 in peripheral blood mononuclear cells of diabetic nephropathy patients were higher than that of the normal controls (78.4±35.67 vs 29.3±17.31pg/ml, P0.05), which were positively related to the level of urinary albumin and the serum creatinine respectively (r=0.633,P0.05;r=0.701,P0.05). MCP-1 level of patients with diabetic nephropaty decreased obviously by Emodian and the decreasing degree were enhanced by the increasing of Emodin density.Conclusion Patients with diabetic nephropaty have higher MCP-1 level compared with normal controls.Emodin could downregulate the express ion of MCP-1, which probably constituted the important parts of the mechanism of Emodin functon as of decreasing urinary protein and improving renal function." @default.
- W2370274271 created "2016-06-24" @default.
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- W2370274271 date "2004-01-01" @default.
- W2370274271 modified "2023-09-23" @default.
- W2370274271 title "The effects of Emodin on MCP-1 secretion in peripheral blood mononuclear cells of patients with diabetic nephropathy" @default.
- W2370274271 hasPublicationYear "2004" @default.
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