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- W2370291950 abstract "Objective: To investigate the autophagy in rat adipose tissue with different high blood glucose models established by short-term concentrated glucose solution infusion or streptozotocin(STZ) injection.Methods: Normal female SD rat(n=36) were divided into 2 groups,glucose infusion group were infused for 72 h with 0.45% NaCl via an inwelling jugular catheter(n=6),and on the 24 h、48 h or 72 h with 50% glucose(6 rats in each group);streptozotocin group received streptozotocin via i.p(n=6)or 0.1 mol/L citrate buffer as control(n=6).Blood glucose were detected before executed and blood were kept for detecting insulin.The change of autophagy-related protein and mRNA in perirenal adipose tissue were measured using Western blotting and real-time PCR respectively.Results: Concentrated glucose solution infusion induced insulin resistance in rat adipose tissue,and increased the expression of autophagy-related proteins LC3,Atg5 and Atg12 gene.The 72h glucose infusion activated autophagy pathway markedly.Although STZ rat showed higher level of blood glucose,there was no marked change in STZ rat compared with control.Conclusion: High blood glucose may not be the main factor that induces autophagy in adipose tissue,upregulation of autophagy in adipose tissue induced by concentrated glucose infusion may be related to insulin resistance." @default.
- W2370291950 created "2016-06-24" @default.
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- W2370291950 date "2011-01-01" @default.
- W2370291950 modified "2023-09-23" @default.
- W2370291950 title "Autophagy in rat perirenal adipose tissue with different high blood glucose models" @default.
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