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- W2370291976 abstract "Objective To study the effect of daidzein on the proliferation of endometrial carcinoma and the mechanism,and to provide the theoretical basis for the application of phytoestrogen.Methods Endometrial carcinoma cell line-Ishikawa was cultured in vitro.The influences of daidzein in different doses on the proliferation of Ishikawa cells were detected by using MTT method,and the changes of estrogen-related receptor-α-mRNA(ERRα-mRNA) and protein level were detected by applying RT-PCR and Western blot method.Results Daidzein inhibited significantly the proliferation of Ishikawa cells in vitro,and the effect was strengthened along with the increase of the dose and the prolong of action time,showing a dose-dependence and time-dependence.Daidzein in low dose(40 mmol/L) had no effects on ERRαmRNA and protein level,but in high dose(≥40 mmol/L) it regulated upward the expression of ERRα.Conclusion Daidzein can inhibit the proliferation of endometrial carcinoma through regulating the expression of ERRα." @default.
- W2370291976 created "2016-06-24" @default.
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- W2370291976 date "2010-01-01" @default.
- W2370291976 modified "2023-09-26" @default.
- W2370291976 title "Effect of daidzein on proliferation of endometrial carcinoma" @default.
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