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- W2370291985 abstract "Objective To observe intracellular NADPH level and ROS production by activating human peripheral white blood cells(WBCs)under the conditions of continuing high glucose and fluctuating high glucose levels after stimulation and to compare the impact of the two conditions on respiratory burst in WBCs.Methods Isolated healthy WBCs were incubated in the medium containing normal glucose(5.5 mmol/L D-Glu),continuing high glucose(16.7 mmol/L D-Glu),or fluctuating high glucose(5.5 mmol/L and 16.7 mmol/L alternatively) for 24 h and then intervened with fMLP for 30 min for activation.Intracellular NADPH contents were assayed by measuring the absorbance of the cell supernatant at 340nm on spectrophotometer.Intracellular ROS was evaluated by flow cytometry.Results As compared with the normal control group,NADPH contents and ROS production in the cells were decreased in the group with continuing high glucose or with fluctuating high glucose after fMLP intervention(P0.05) and the effect of fluctuating glucose was more obvious(P 0.05).Conclusions Continuing high glucose and fluctuating high glucose concentration decrease intracellular NADPH contents and the ability of WBCs to produce ROS.The effect of the latter one was more obvious,leading to the impairment of respiratory burst in the cells." @default.
- W2370291985 created "2016-06-24" @default.
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- W2370291985 date "2009-01-01" @default.
- W2370291985 modified "2023-09-23" @default.
- W2370291985 title "Effects of glucose variability on NADPH level and ROS production in healthy human peripheral white blood cells" @default.
- W2370291985 hasPublicationYear "2009" @default.
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