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- W2370293902 abstract "Objective To investigate the changes of plasma glucagon and gastric mucosal blood flow (GMBF) in rats with portal hypertensive gastropathy(PHG).Methods Sprague Dawley rats were separated two groups by random:portal hypertensive group (PHT) and sham operated group(SO).The portal hypertensive models were established by portal vein ligation.14 days after surgery either a portal vein ligated group or sham operated group,the portal vein pressure(PVP),the gastric mucosal blood flow(GMBF) in antrum and fundus were measured,the concentration of plasam glucagon was detected through radioimmunoassay.Results The portal vein pressure(2 65±0 30kPa) and the gastric mucosal blood flow(116 21±13 40BPU) in fundus were significantly higher in the portal hypertensive rats than that in the sham operated rats(1 13±0 11kPa?79 01±11 66BPU,respectively)( P 0 01 or P 0 05 respectively). The gastric mucosal blood flow in antrum showed no significant difference between the PHT group rats and the SO group rats( P 0 05). The concentration of plasam glucagon in PHT rats (261 29±18 48pg/ml) was significantly higher than that in SO rats(63 61±6 01pg/ml( P 0 01).Conclusion Portal hypertensive gastropathy may be related to hyperperfusion of gastric mucosa. Glucagon may be play a role in the hyperperfusion of gastric mucosa." @default.
- W2370293902 created "2016-06-24" @default.
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- W2370293902 date "2002-01-01" @default.
- W2370293902 modified "2023-09-25" @default.
- W2370293902 title "An experimental study on the pathogenesis of portal hypertensive gastropathy" @default.
- W2370293902 hasPublicationYear "2002" @default.
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