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- W2370294749 abstract "AIM: To study the effect of hypoxia and hypercapnia on nitric oxide (NO) in plasma and superoxide dismutase (SOD), catalase (CAT), soluble guanylate cyclase (sGC), cyclic guanosine monophospholate (cGMP) in lung tissue in rats, and to explore the effect of NO- and H_2O_2-sGC pathway on the development of the pulmonary hypertension. METHODS: The model of hypoxic and hypercapnic 1, 2, 4-week group (HH 1 week, HH 2 weeks, HH 4 weeks) and control group was set up. NO content in plasma, CAT and SOD in rat lung were determined by spectrophotometry. The sGC activity in lung tissue was detected by enzyme kinetic analysis. cGMP content in lung tissue was examined with ~ 125 I-radioimmunoassay. RESULTS: The mean pulmonary artery pressure (mPAP) showed significantly higher in HH 1 week, HH 2 weeks and HH 4 weeks groups compared with control group (all P0.05). NO concentration in plasma, CAT, SOD, basal or nitroprusside-or H_2O_2- stimulated sGC activity and cGMP concentration in lung homogenates were significantly lower (P0.05, P0.01, P0.01, respectively) in HH 1 week, HH 2 weeks and HH 4 weeks groups compared with control group. CONCLUSION: The inhibition of NO- and H_2O_2-sGC pathway by hypoxia and hypercapnia plays an important role in the development of pulmonary hypertension." @default.
- W2370294749 created "2016-06-24" @default.
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- W2370294749 date "2006-01-01" @default.
- W2370294749 modified "2023-09-25" @default.
- W2370294749 title "Changes of NO- and H_2O_2-dependent soluble guanylate cyclase pathway in the hypoxic hypercapnic pulmonary hypertension rats" @default.
- W2370294749 hasPublicationYear "2006" @default.
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