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- W2370295573 abstract "【Objective】 To explore the changes of plasma cardiotrophin-1(CT-1) and its significance in patients with chronic heart failure (CHF).【Methods】 We studied 106 chronic heart failure patients (NYHA function class Ⅱ41 cases,class Ⅲ 36 cases,class Ⅳ 29 cases) and 35 healthy control subjects.Plasma CT-1 concentrations were measured with ABC-ELISA method.Plasma BNP concentrations were measured with FIA method.【Results】 Plasma levels of CT-1 and BNP in CHF patients were higher than those in control group [CT-1: (448.5 ± 66.3) pg/mL vs (78.6 ± 13.6) pg/mL,P 0.01;BNP: (258.9±76.2) pg/mL vs (65.4 ± 32.8) pg/mL,P 0.01].Plasma levels of CT-1 and BNP increased with severity of CHF and there were significant differences among different groups of the CHF patients (P 0.05,P 0.01).Meanwhile,LVEF in CHF patients decreased with the increasing of the plasma levels of CT-1 and BNP.There was a significant negative correlation between plasma CT-1 and LVEF (r =-0.316,P 0.01).Plasma levels of BNP were positively correlated with the age,systolic blood pressure,diastolic blood pressure and serum creatinine (r =0.213,P 0.05;r =0.306,P 0.01;r =0.264,P 0.01;r =0.371,P 0.01),and were negatively correlated with LVEF(r =-0.521,P 0.01).【Conclusion】 Plasma CT-1 level is a possible marker of reflecting the severity of heart failure and maybe more sensitive at predicting the severity in patients with heart failure than BNP." @default.
- W2370295573 created "2016-06-24" @default.
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- W2370295573 date "2010-01-01" @default.
- W2370295573 modified "2023-09-26" @default.
- W2370295573 title "Changes and significance of plasma cardiotrophin-1 in patients with chronic heart failure" @default.
- W2370295573 hasPublicationYear "2010" @default.
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