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- W2370296257 abstract "Objective To study the induction of cisplatin on apoptosis of human glioma SHG-44neurospheres,and to explore its mechanism.Methods The SHG-44neurospheres were cultured and divided into control and cisplatin groups.The cells in control group were treated with stem cells media,and based on control group,the cells in cisplatin group were treated with 10mg·L-1 cisplatin for 24,48and 72h.MTT assay was used to evaluate the inhibitory rate of proliferation of SHG-44neurospheres;the morphology of the cells was observed by inverted microscope;the levels of Bax,Bcl-2,and caspase-3proteins secreted by SHG-44neurospheres were detected by ELISA assay.Results Compared with control group,the inhibitory rates of SHG-44neurospheres in cisplatin group were increased after treated for 24,48and 72h(P0.01).The apoptotic bodies were observed and the number of neuroshperes were reduced in cisplatin group under inverted microscope.Compared with control group,the levels of Bax and Bcl-2were decreased,the level of caspase-3was increased,and the ratio of Bax/Bcl-2was significantly increased in cisplatin group(P0.05or P0.01).Conclusion Cisplatin could significantly inhibit the growth of SHG-44neurospheres and induce apoptosis,and its mechanism may be related to up-regulating the ratio of Bax/Bcl-2and giving the apoptosis factors the advantage." @default.
- W2370296257 created "2016-06-24" @default.
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- W2370296257 date "2013-01-01" @default.
- W2370296257 modified "2023-09-24" @default.
- W2370296257 title "Induction of cisplatin on apoptosis of glioma neurospheres and its mechanism" @default.
- W2370296257 hasPublicationYear "2013" @default.
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