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- W2370297867 abstract "Objective To study the efficacy and safety of autologous peripheral blood stem cells transplantation(APBSCT)therapy for multiple myeloma(MM) patients with renal involvement.Methods Four male patients,aged 35 to 53 years,diagnosed as MM with renal involvement were enrolled.All patients had undergone routine biochemical test,blood and urine immunoelectrophoresis,and bone marrow biopsy,and renal biopsy were performed in three of them.All of them received high-dose chemotherapy(HDT) with APBSCT after 4-6 cycles of chemotherapy.Results Two patients were IgG type,1 was IgD type,and the other was non-secretory type.According Durie-Salmon staging system,two cases were stageⅡA,1 patient was stage ⅢA,and the other was stage ⅢB.All patients had proteinuria(1.51-5.70 g/d);2 patients suffered from acute kidney injury,1 patient was in chronic kidney disease(CKD) stage Ⅱ,1 was in CKD stage Ⅴ.Renal biopsies showed focal segmental glomerulosclerosis(FSGS) with diffuse interstitial infiltration of inflammatory cells in 1 patient,light chain deposition disease(LCDD) in 1 case,and myeloma cast nephropathy(MCN) in 1 case;1 patient without renal biopsy was suspected of MCN.In 3 patients with mild to moderate renal involvement,acute kidney injury recurred in 1 patient after APBSCT but recovered within a short time;all 3 patients had proteinuria turned to negative and stable renal function during follow-up.One year later,1 case died because of turning to plasma cell leukemia,and the other 2 cases remained in complete remission(CR).The patients with severe renal involvement(CKD stage Ⅴ) died of septic shock after APBSCT.Conclusions HDT combined with APBSCT is an effective treatment for MM,which can be used safely in MM patients with mild to moderate renal involvement,renal function was not adversely affected by APBSCT obviously,and effect of APBSCT was satisfactory.Further study is needed for addressing whether APBSCT could be used safely in patients with severe renal insufficiency." @default.
- W2370297867 created "2016-06-24" @default.
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- W2370297867 date "2011-01-01" @default.
- W2370297867 modified "2023-09-24" @default.
- W2370297867 title "Autologous peripheral blood stem cell transplantation in multiple myeloma patients with renal involvement" @default.
- W2370297867 hasPublicationYear "2011" @default.
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