Matches in SemOpenAlex for { <https://semopenalex.org/work/W2370306734> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2370306734 abstract "Objective: To assess potential mechanisms responsible for the antitumor activities of the streptococcal preparation OK 432.Methods: C57BL/6 mice were transplanted subcutaneously with 5×10 5 B16 melanoma cells and treated with OK 432 (1KE/week×3) or saline (control) intraperitoneally 3 days after the inoculation and tumor size was measured biweekly. The effects of OK 432 on splenocyte cytokines (IL 2, IL 4, IL 6, IL 10, IL 12, IFN γ) production of tumor bearing mice were investigated both in vitro and in vivo. Results: OK 432 significantly inhibited B16 melanoma growth and lengthened the survival time of the mice as compared with control ( P 0.05). When splenocytes of tumor bearing mice were stimulated with OK 432 in vitro , the level of IL 6, IL 12, IFN γ and IL 10 in the conditional media was increased markedly ( P 0.01). The spontaneous production of IL 2, IL 12 and IFN γ of plenocytes derived from OK 432 treated mice was higher and IL 10 was lower than that of untreated mice. When the splenocytes were stimulated with OK 432 again in vitro , the production of IFN γ increased and IL 10 decreased significantly as compared with untreated mice ( P 0.05). Conclusion: These results indicated OK 432 effectively inhibited B16 melanoma growth and the mechanism showed in this experiment was that OK 432 boosted multiple cytokines production, especially IL 12 which skewed T cells in a Th1 dominant state and enhanced the host antitumor activities." @default.
- W2370306734 created "2016-06-24" @default.
- W2370306734 creator A5001461011 @default.
- W2370306734 date "2001-01-01" @default.
- W2370306734 modified "2023-09-25" @default.
- W2370306734 title "OK-432 Induced IL-12 and Th1 Cytokines Production in Tumor Bearing Mice" @default.
- W2370306734 hasPublicationYear "2001" @default.
- W2370306734 type Work @default.
- W2370306734 sameAs 2370306734 @default.
- W2370306734 citedByCount "0" @default.
- W2370306734 crossrefType "journal-article" @default.
- W2370306734 hasAuthorship W2370306734A5001461011 @default.
- W2370306734 hasConcept C134018914 @default.
- W2370306734 hasConcept C150903083 @default.
- W2370306734 hasConcept C16685009 @default.
- W2370306734 hasConcept C185592680 @default.
- W2370306734 hasConcept C189976730 @default.
- W2370306734 hasConcept C191732599 @default.
- W2370306734 hasConcept C202751555 @default.
- W2370306734 hasConcept C203014093 @default.
- W2370306734 hasConcept C207001950 @default.
- W2370306734 hasConcept C2777397205 @default.
- W2370306734 hasConcept C2777658100 @default.
- W2370306734 hasConcept C2778690821 @default.
- W2370306734 hasConcept C502942594 @default.
- W2370306734 hasConcept C55493867 @default.
- W2370306734 hasConcept C71924100 @default.
- W2370306734 hasConcept C74172505 @default.
- W2370306734 hasConcept C86803240 @default.
- W2370306734 hasConceptScore W2370306734C134018914 @default.
- W2370306734 hasConceptScore W2370306734C150903083 @default.
- W2370306734 hasConceptScore W2370306734C16685009 @default.
- W2370306734 hasConceptScore W2370306734C185592680 @default.
- W2370306734 hasConceptScore W2370306734C189976730 @default.
- W2370306734 hasConceptScore W2370306734C191732599 @default.
- W2370306734 hasConceptScore W2370306734C202751555 @default.
- W2370306734 hasConceptScore W2370306734C203014093 @default.
- W2370306734 hasConceptScore W2370306734C207001950 @default.
- W2370306734 hasConceptScore W2370306734C2777397205 @default.
- W2370306734 hasConceptScore W2370306734C2777658100 @default.
- W2370306734 hasConceptScore W2370306734C2778690821 @default.
- W2370306734 hasConceptScore W2370306734C502942594 @default.
- W2370306734 hasConceptScore W2370306734C55493867 @default.
- W2370306734 hasConceptScore W2370306734C71924100 @default.
- W2370306734 hasConceptScore W2370306734C74172505 @default.
- W2370306734 hasConceptScore W2370306734C86803240 @default.
- W2370306734 hasLocation W23703067341 @default.
- W2370306734 hasOpenAccess W2370306734 @default.
- W2370306734 hasPrimaryLocation W23703067341 @default.
- W2370306734 hasRelatedWork W146127512 @default.
- W2370306734 hasRelatedWork W1566351800 @default.
- W2370306734 hasRelatedWork W1900999978 @default.
- W2370306734 hasRelatedWork W2048623067 @default.
- W2370306734 hasRelatedWork W2335671019 @default.
- W2370306734 hasRelatedWork W2410936031 @default.
- W2370306734 hasRelatedWork W2415354967 @default.
- W2370306734 hasRelatedWork W2415571271 @default.
- W2370306734 hasRelatedWork W2419304222 @default.
- W2370306734 hasRelatedWork W2419375024 @default.
- W2370306734 hasRelatedWork W2423620216 @default.
- W2370306734 hasRelatedWork W2436021668 @default.
- W2370306734 hasRelatedWork W2466531220 @default.
- W2370306734 hasRelatedWork W2555045297 @default.
- W2370306734 hasRelatedWork W2626352248 @default.
- W2370306734 hasRelatedWork W2952524263 @default.
- W2370306734 hasRelatedWork W3030174797 @default.
- W2370306734 hasRelatedWork W3153809499 @default.
- W2370306734 hasRelatedWork W167271329 @default.
- W2370306734 hasRelatedWork W3151350742 @default.
- W2370306734 isParatext "false" @default.
- W2370306734 isRetracted "false" @default.
- W2370306734 magId "2370306734" @default.
- W2370306734 workType "article" @default.