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- W2370320143 abstract "Objective To investigate the therapeutic effect of cinnamaldehyde(CA)on mice viral myocarditis caused by coxsackievirus B3(CVB3). Methods One hundred and seventy male Balb/c mice were randomly divided into 6 groups.The mice in the control group(n=20)was i.p injected with normal saline,those in other five groups(n=30 in each)were inoculated with Coxsackievirus B3m virus and bred in insulation lab.After viral inoculated for 72 h,Groups CA were i.g injected with CA at dose of 22.5,28.1,37.5 mg·kg-1 ,respectively.Model group was treated with normal saline; Group RA was i.p.treated with 50 mg·kg-1 Radix astragali injective solution(RA) as a positive control.All groups were treated for 10 d.The heart histopathologic changes,content of CK,CK-MB,LDH and NO in serum,and iNOS,NF-κB in myocardium were detected. Results The histopathologic score,death rate,median survival time,and the content of CK,CK-MB,LDH in serum were lower in 22.5,28.1,37.5 mg·kg-1 CA groups than those in the model group at 7 d after viral inoculation(P0.05).The content of NO in serum,expression of NF-κB and iNOS in myocardium were lower in 22.5,28.1,37.5 mg·kg-1 CA groups than those in model group at 14 d after viral inoculation(P0.05).The histopathologic changes (necrosis,degeneration and cellular infiltration) were lighter in CA groups than those in model group at 21 d after viral inoculation. Conclusion CA has a significant therapeutic effect on experimental VMC,the mechanism of which may be associated with inhibition of NF-κB and iNOS expressions." @default.
- W2370320143 created "2016-06-24" @default.
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- W2370320143 date "2009-01-01" @default.
- W2370320143 modified "2023-09-26" @default.
- W2370320143 title "Effect of Cinnamaldehyde on Mice Viral Myocarditis Caused by CVB_3m" @default.
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