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- W2370351108 abstract "Objective The aim of this study is to explore the inhibitory effect of transmembrane Tim-3 on H22 hepatocarcinoma and the potential effect on immune system of mice loaded with H22 hepatocarcinoma.Methods Tumor model was established by inoculation of H22 hepatocarcinoma cells at the hind thigh of BALB/c mice.Recombinant vector plasmids were transfected at the same site for gene therapy by injection.Inhibitory effect of Tim-3 on tumor growth was observed.A panel of genes including 4-1BB,IFN-γand galectin-9 from tumor tissues at different time points were ana- lyzed by RT-PCR.The proliferation and cytotoxicity of splenocytes after Tim-3 transfection were e- valuated by flow cytometry.Synergistic effect of Tim-3 with 4-1BBL against tumor was also evalua- ted.Results Growth of tumor was suppressed evidently with the transfection of Tim-3.Flow cytom- etry showed that the proliferation of splenocytes and cytolysis to tumor cells detected in early phase of tumor development were enhanced in the presence of Tim-3,and this anti-tumor effect was further improved by the combined use of Tim-3 with 4-1BBL Conclusion Transmembrane Tim3 may act as a positive immunoregulator in the initiation of immunity to enhance anti-tumor immune responses and has synergistic effect with 4-1BBL in anti-tumor immunity." @default.
- W2370351108 created "2016-06-24" @default.
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- W2370351108 date "2007-01-01" @default.
- W2370351108 modified "2023-09-23" @default.
- W2370351108 title "Membran-type Tim3 Promotes Anti-turmor Immunity in Turmor-bearing Mice" @default.
- W2370351108 hasPublicationYear "2007" @default.
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