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- W2370356989 abstract "Objective To explore the relationship and mechanism between intrauterine infection and brain injury in preterm infants. Methods Eighty-five preterm infants who were born in Fogang People′s Hospital from Jun.2008 to Jun.2010 were enrolled.All the placentas were collected and pathologically examined for the confirmation of intrauterine infection,and cord blood samples from each baby were collected and sent for the determination of cytokine IL-1β,IL-6,tumor necrosis factor(TNF)-α,IL-10 levels by enzyme-linked immumosorbent assay;Brain injury was judged by the findings of cranial ultrasound or CT scan,the Neonatal Behavioral Neurological Assessment(NBNA),and early motor development index,which were done within 3-7 days after birth in every baby.All the babies were divided into 2 groups by above evidence of brain injury. Results 1.Maternal chorioamnionitis occurred in 33% of all preterm mothers(28/85 cases);Brain injury was showed in 46% of all preterm infants whose mothers suffered from maternal chorioamnionitis(13/28 cases),while only in 7% of those babies whose mothers did not(4/57 cases),with the former being significant higher(χ~2=15.84,P0.05).2.Cord blood levels of IL-1β,IL-6,TNF-α in babies with brain injury were(6.53±3.17) μg·L~-1,(7.95±4.32) μg·L~-1 and(5.43±1.82) μg·L~-1,respectively,significantly higher than those without brain injury[(1.53±1.22) μg·L~-1,(1.65±2.10) μg·L~-1 and(3.23±0.83) μg·L~-1,respectively];IL-10 level in babies with brain injury was(1.21±0.23) μg·L~-1,much lower than that without brain injury[(1.59±0.25) μg·L~-1](P_a0.05). Conclusion Intrauterine infection may play a role in brain injury in preterm infants,and cytokines may be the key mediator of the injury." @default.
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- W2370356989 date "2011-01-01" @default.
- W2370356989 modified "2023-09-25" @default.
- W2370356989 title "Relationship between Intrauterine Infection and Brain Injury in Preterm Infants" @default.
- W2370356989 hasPublicationYear "2011" @default.
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