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• W2370363384 abstract "Objective To investigate the effect of kanamycin ototoxicity on guinea pigs cochlear cells apoptosis,and relation between signal transportation of caspase3 and apoptosis of cochlear cellsMethods Fifty guinea pigs were randomly divided into 5 groupsExperiment groups were intramuscularly injected with kanamycin 200 mg/(kg·d) for 14 days consecutivelyGuinea pigs of control group and experiment group 1 d,3 d,7 d,14 d were sacrificed respectivelyAuditory brainstem response (ABR) and cochlea cells apoptosis were detected by TUNEL technology,and expression of caspase3 was tested by immunohistochemical method at different timesResults The ABR threshold of experimental group were apparently higher than control animals following the time was longer,the apoptosis of cochlear cells was more increased and those in basal turn were more than apical turn,the expression of caspase3 rose up gradually,and significant difference was observed compared with control group (P 001)Conclusion Chronic kanamycin ototoxicity has relationship with cochlear cells apoptosis,caspase3 cascade has important effect on the course of cochlear cells apoptosis" @default.
• W2370363384 created "2016-06-24" @default.
• W2370363384 creator A5019822677 @default.
• W2370363384 date "2005-01-01" @default.
• W2370363384 modified "2023-09-23" @default.
• W2370363384 title "Apoptosis and caspase-3 expression of guinea pigs cochlear cells with kanamycin ototoxicity" @default.
• W2370363384 hasPublicationYear "2005" @default.
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